Elite Bioscience

GHK-Cu 50mg (Copper Peptide)

In laboratory and experimental research settings, GHK-Cu has been investigated in relation to:

  • Extracellular matrix (ECM) synthesis and remodeling
  • Collagen, elastin, and proteoglycan regulation
  • Anti-inflammatory and antioxidant signaling pathways
  • Angiogenesis and microvascular repair
  • Epithelial and dermal regeneration research
  • Hair follicle cycling and dermal papilla activity
  • Neuroprotective and redox-balance mechanisms

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GHK-Cu is a naturally occurring copper-binding tripeptide complex composed of glycyl-L-histidyl-L-lysine (GHK) chelated with a Cu² ion. It is commonly investigated for its role in tissue remodeling, extracellular matrix regulation, inflammatory modulation, and regenerative signaling. Researchers utilize GHK-Cu in laboratory studies examining connective tissue dynamics, skin and epithelial regeneration, vascular integrity, and oxidative-stress balance due to its broad influence on cellular signaling and gene-expression pathways.

Current laboratory and animal research suggests GHK-Cu may influence several interconnected biological processes:

Extracellular Matrix (ECM) Remodeling

GHK-Cu stimulates fibroblast activity and has been associated with increased synthesis of collagen, elastin, decorin, and glycosaminoglycans—key structural components studied in connective-tissue research.

MMP Regulation & Tissue Remodeling

Research indicates modulation of matrix metalloproteinases (MMP-2 and MMP-9) alongside increased tissue inhibitor (TIMP) activity, supporting balanced ECM turnover and reconstruction.

Anti-Inflammatory & Antioxidant Activity

GHK-Cu has been shown to enhance antioxidant enzyme activity and reduce pro-inflammatory cytokine signaling, positioning it as a compound of interest in oxidative-stress and inflammation research.

Wound Repair & Re-epithelialization

Experimental studies report accelerated keratinocyte migration, enhanced angiogenic signaling, and improved wound-closure dynamics in controlled injury settings.

Copper Transport & Redox Modulation

As a natural copper carrier, GHK-Cu influences superoxide dismutase (SOD) activity, cellular redox balance, and copper-dependent enzymatic processes in damaged tissue research.

Hair Follicle & Dermal Research

Copper peptides have been associated with increased follicular size, delayed regression phases, and stimulation of dermal papilla cells in hair-cycle research environments.

Gene Expression Regulation

Transcriptomic analyses demonstrate that GHK-Cu upregulates genes linked to repair and regeneration while downregulating those associated with inflammation and fibrosis.

Elite Bioscience supplies GHK-Cu strictly for laboratory, analytical, and in-vitro research.

“Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of New Gene Data.”

Large-scale gene-expression analysis demonstrated activation of repair-related pathways alongside downregulation of inflammatory and fibrotic gene networks, positioning GHK-Cu as a broad regulator of regenerative signaling.

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“The Human Tri-peptide GHK and Tissue Remodeling.”


This study demonstrated that the copper tripeptide GHK-Cu significantly influenced gene expression patterns associated with tissue remodeling, antioxidant defense, and inflammatory regulation. Transcriptomic analysis showed upregulation of genes involved in extracellular matrix organization and cellular repair, alongside downregulation of genes linked to inflammation and tissue degradation, supporting GHK-Cu’s relevance in regenerative and cellular maintenance research.

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In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex in rat experimental wounds

This study demonstrated that the copper tripeptide GHK-Cu significantly increased collagen production in human fibroblast cultures by upregulating collagen mRNA expression. The findings support GHK-Cu’s relevance in research exploring extracellular matrix synthesis, connective tissue maintenance, and cellular repair signaling, without affecting TGF-β expression.

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“GHK-Cu May Prevent Oxidative Stress in Skin.”


Gene-expression profiling revealed upregulation of antioxidant pathways and suppression of inflammatory mediators in skin research contexts.

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“GHK-Cu Liposomes Accelerate Scald Wound Healing in Mice.”


Encapsulated GHK-Cu enhanced angiogenesis, cellular proliferation, and wound-closure efficiency compared to non-encapsulated forms in injury research models.

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Chemistry

Supplier: Elite Bioscience®
Product Form: 1 × 50 mg sterile, lyophilized peptide vial
Active Ingredient: GHK-Cu (Copper Tripeptide-1)
Chemical Name:
6-Amino-2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid copper complex
Peptide Class: Copper-binding tripeptide (Gly-His-Lys + Cu²)
Research Use: For laboratory, in-vitro, and analytical research only. Not for human or veterinary use.

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