A controlled clinical study investigating Epitalon in patients with retinitis pigmentosa reported positive clinical responses in approximately 90% of participants, including improvements in visual acuity, expansion of visual-field borders, and reduction of scotomas. These findings support Epitalon’s relevance in research focused on retinal degeneration and pineal peptide signaling.


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A prospective observational study involving 266 elderly individuals receiving Epithalamin (the parent pineal extract from which Epitalon is derived) reported 1.6- to 4.1-fold reductions in mortality over a six-year observation period compared to controls. While this study did not directly administer synthetic Epitalon, it provides contextual evidence for the biological relevance of pineal-derived peptides in aging-related research.


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In spontaneously hypertensive (SHR) mice, monthly Epitalon administration increased lifespan by approximately 12.3–13.3%, reduced chromosomal aberrations, and inhibited leukemia development without increasing overall tumor incidence. These findings position Epitalon as a compound of interest in experimental models of lifespan regulation and genomic stability.


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A comprehensive experimental study examining Epitalon across multiple animal models reported: Activation of telomerase in normal somatic cells, Reduction in oxidative-stress markers, Extension of lifespan in treated populations. Importantly, telomerase activation was observed in non-tumor cells, a distinction emphasized throughout the study’s analysis.


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