In laboratory and neuroendocrine research settings, Melanotan II has been investigated in relation to:
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Melanotan II (MT-2) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH), a naturally occurring peptide involved in melanocortin receptor signaling. It was originally developed as a research compound to study melanogenesis and pigmentation mechanisms through activation of melanocortin receptors, particularly MC1R. Researchers utilize Melanotan II in laboratory studies exploring melanocortin system biology, central receptor signaling, and downstream physiological pathways influenced by α-MSH activity.
Research suggests Melanotan II is involved in several key biological processes related to melanocortin signaling:
Melanocortin Receptor Activation
Melanotan II acts as a non-selective agonist of melanocortin receptors (MC1R–MC5R), allowing investigation of receptor-specific and central melanocortin pathways.
Melanogenesis & Pigmentation Signaling
Activation of MC1R on melanocytes promotes eumelanin production, making Melanotan II a reference compound in pigmentation and UV-response research models.
Central Nervous System Signaling
MC3R and MC4R activation links Melanotan II to hypothalamic and limbic signaling pathways involved in autonomic, behavioral, and neuroendocrine regulation.
Appetite & Energy Regulation
Melanocortin signaling plays a known role in appetite suppression and energy balance, positioning Melanotan II as a research tool for metabolic and feeding-behavior studies.
Sexual & Autonomic Pathways
Preclinical and limited human research has examined melanocortin involvement in sexual and autonomic nervous system responses, though findings remain exploratory and incomplete.
Elite Bioscience supplies Melanotan II strictly for laboratory, analytical, and in-vitro research.
A small single-blind, placebo-controlled phase I study in healthy adult males demonstrated that Melanotan II induced skin pigmentation changes and central melanocortin-mediated effects, including autonomic responses, at low doses.
Read StudyThis review outlines how Melanotan II interacts with melanocortin receptors (MC1R, MC3R, MC4R) in experimental models, influencing melanogenesis, appetite regulation, and neurobehavioral signaling. The findings provide mechanistic context for Melanotan II’s activity in pigmentation and central melanocortin pathways, with evidence remaining primarily preclinical.
Read StudySupplier: Elite Bioscience®
Product Form: 1 × 10 mg sterile, lyophilized peptide vial
Active Ingredient: Melanotan II (MT-2)
Peptide Class: Synthetic α-MSH analog (melanocortin receptor agonist)
Research Use: For laboratory, in-vitro, and analytical research only. Not for human or veterinary use.