Hormone Optimization Research Guide

Growth hormone (GH) release is regulated by a complex interplay of stimulatory (GHRH) and inhibitory (somatostatin) signals. Research peptides can modulate this axis at multiple points — GH-releasing peptides (GHRPs) act on ghrelin receptors while GHRH analogs act on the GHRH receptor.

CJC-1295 (modified GHRH analog), Ipamorelin (selective GHRP), Sermorelin (GHRH analog), and Tesamorelin (GHRH analog with lipodystrophy applications) are the most studied growth hormone secretagogues. Each offers distinct selectivity and pulsatile release profiles.

The CJC-1295/Ipamorelin combination is widely researched for its synergistic GH release pattern. CJC-1295 provides a sustained GHRH signal while Ipamorelin provides a selective GH pulse, avoiding cortisol and prolactin elevation seen with other GHRPs.

Epithalon (a synthetic tetrapeptide) and NAD+ are studied for their roles in telomerase activation and cellular energy, respectively. These compounds represent a different approach to age-related research — addressing fundamental cellular mechanisms rather than hormonal signaling.